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KMID : 1035620130010010084
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Allergy Asthma & Respiratory Disease
2013 Volume.1 No. 1 p.84 ~ p.89
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The clinical characteristics in infantile bronchiolitis and pneumonia according to respiratory syncytial virus subgroups: experience of single tertiary medical center from 2010 to 2012
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Yooon Ga-Hyun
Kim Yeo-Hyang
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Abstract
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Purpose:The most common cause of bronchiolitis and pneumonia in infants is respiratory syncytial virus (RSV). We evaluated the clinical characteristics according to RSV subgroup in infantile bronchiolitis and pneumonia.
Methods: This study enrolled infants with bronchiolitis or pneumonia infected by single virus. Virus infection was confirmed by respiratory virus reverse transcriptase polymerase chain reaction in two consecutive seasons (2010-2011, 2011-2012). They were divided into 3 groups: group 1 with RSV A, group 2 with RSV B, and group 3 with other virus. We retrospectively reviewed the medical charts to collect data on the hospitalized patients.
Results: Seventy four and 181 infants were included in the two seasons, respectively. The most common virus was RSV B in 2010-2011 and RSV A in 2011.2012. Among 255 infants, 55% (141/255) were group 1, 20% (49/255) group 2, 25% (65/255) group 3. Infants younger than 3 months were 55%. There were no significant age differences between groups. In comparison to group 3, group 1 and 2 showed frequent abnormal chest auscultation, high symptom severity score and need for systemic corticosteroid (P<0.05). In comparison to group 1 and 3, group 2 had longer hospitalization and time to need for normalization of lung sound (P<0.05). The recurrence rates within 6 months showed no significant differences between groups.
Conclusion: The RSV subgroup changed from one year to another. Patients’ clinical manifestations and symptom severity may vary according to infected virus subgroup.
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KEYWORD
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Infant, Respiratory syncytial viruses, Bronchiolitis, Pneumonia
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